B12 Methylcobalamin
The active, bioavailable form of vitamin B12. Important in DNA synthesis, nerve cell function, and red blood cell production. Injectable methylcobalamin bypasses GI absorption issues to deliver optimal B12 levels directly to cells.
3-month program. Upfront payment: $360 ($120/month for 3 months).
Prescription required. Provided by board-certified physicians.
Description
Methylcobalamin is the active, coenzyme form of vitamin B12 (cobalamin), meaning it is immediately available for use by the body without requiring metabolic conversion. It serves as a vital cofactor in DNA synthesis and cellular division, is essential for maintaining the myelin sheath that protects nerve cells, and functions as a methyl donor in the metabolism of homocysteine to methionine—helping to maintain healthy homocysteine levels.
While vitamin B12 is naturally present in animal-based foods, many individuals develop deficiency despite adequate dietary intake. Common causes include impaired absorption due to decreased intrinsic factor or stomach acid production (which naturally decline with age), gastrointestinal conditions such as pernicious anemia, Crohn's disease, or celiac disease, certain medications including metformin and proton pump inhibitors, and dietary restrictions such as vegetarian or vegan diets.
Injectable methylcobalamin bypasses the digestive system entirely, providing direct absorption into the bloodstream regardless of gastrointestinal function or intrinsic factor availability. This ensures optimal bioavailability and can effectively correct deficiency states. Because methylcobalamin is already in its active form, it may offer advantages for neurological support and individuals with genetic variations affecting B12 metabolism.
What To Expect
B12 methylcobalamin injections are typically administered intramuscularly or subcutaneously. Many patients experience noticeable improvements in energy levels, mental clarity, and overall well-being within days to weeks of beginning treatment, particularly if deficiency was present prior to therapy. Neurological symptoms may take longer to improve and require consistent supplementation.
Treatment frequency depends on the severity of deficiency, underlying causes, and individual response to therapy. Maintenance protocols commonly range from weekly to monthly injections. Your healthcare provider may recommend baseline and follow-up laboratory testing to assess B12 levels, complete blood counts, and methylmalonic acid or homocysteine levels to guide treatment decisions.
How To Use
B12 methylcobalamin injections are administered by a healthcare provider or self-administered following proper training. Typical maintenance dosing involves injections every 1–4 weeks, depending on individual needs and provider recommendations. Always follow your provider's specific instructions regarding dosage, injection technique, and administration schedule.
Safety Information
B12 methylcobalamin injections are considered very safe with minimal risk of adverse effects, as excess B12 is readily excreted by the kidneys. Potential side effects are rare but may include mild injection site reactions, temporary diarrhea, itching, or allergic reactions in sensitive individuals. Inform your provider if you have Leber's disease (a rare hereditary eye condition), polycythemia vera, or any known allergies to cobalamin or cobalt.