Estradiol Capsules
Oral bioidentical estradiol (E2) used in hormone replacement therapy to treat symptoms of menopause, such as hot flashes, night sweats, vaginal dryness, and bone loss. Helps restore hormonal balance in women with declining estrogen levels.
3-month program. Upfront payment: $180 ($60/month for 3 months).
Prescription required. Provided by board-certified physicians.
Description
Estradiol is the most potent and biologically active form of estrogen naturally produced by the ovaries during the reproductive years. As the primary estrogen in premenopausal women, estradiol plays critical roles in numerous physiological systems including reproductive health, bone metabolism, cardiovascular function, cognitive processes, skin and tissue integrity, and mood regulation.
During perimenopause and menopause, ovarian estradiol production declines significantly, often resulting in a constellation of symptoms that can substantially impact quality of life. Common symptoms include vasomotor symptoms such as hot flashes and night sweats, genitourinary changes including vaginal dryness and atrophy, sleep disturbances, mood changes, cognitive changes, and accelerated bone loss that increases fracture risk.
Oral estradiol capsules provide bioidentical hormone replacement, delivering estradiol that is molecularly identical to the hormone produced by the human body. Oral administration is convenient and allows for consistent daily dosing. Estradiol therapy can effectively alleviate vasomotor symptoms, improve vaginal and urogenital health, support bone density, and enhance overall quality of life. For women with an intact uterus, estradiol must be combined with progesterone therapy to protect the endometrial lining.
What To Expect
Estradiol capsules are taken orally, typically once daily at the same time each day to maintain steady hormone levels. Many women experience significant reduction in hot flashes and night sweats within 2–4 weeks of beginning therapy, with maximal symptom relief often achieved by 8–12 weeks. Improvements in vaginal dryness, sleep quality, mood, and energy typically emerge more gradually over 2–3 months.
Individual response varies based on baseline hormone levels, symptom severity, dosage, and overall health status. Your provider will determine the appropriate starting dose and may adjust it based on symptom response and laboratory results. Some women may experience mild breast tenderness, bloating, or spotting during the initial adjustment period, which typically resolves as the body adapts to therapy.
How To Use
Take one capsule by mouth at the same time each day, with or without food, or as directed by your healthcare provider. Swallow capsules whole with water. Do not crush, chew, or open capsules. Consistent daily administration is important for maintaining stable hormone levels and optimal symptom control. If you miss a dose, take it as soon as you remember unless it is close to the time of your next dose.
Safety Information
Estrogen therapy carries certain risks and is contraindicated in women with a history of breast cancer, estrogen-dependent tumors, active or history of blood clots or stroke, active liver disease, or unexplained vaginal bleeding. Potential side effects may include nausea, breast tenderness, headache, bloating, or mood changes. Long-term estrogen use may increase the risk of blood clots, stroke, cardiovascular events, and certain cancers. Women with an intact uterus must use progesterone in combination with estrogen to protect the uterine lining. The lowest effective dose for the shortest duration necessary should be used.