Progesterone Capsules
An oral hormone replacement therapy containing micronized bioidentical progesterone. Available in both immediate-release (IR) and sustained-release (SR) formulations, used to treat symptoms of hormonal imbalance and provide endometrial protection in women receiving estrogen therapy.
3-month program. Upfront payment: $180 ($60/month for 3 months).
Prescription required. Provided by board-certified physicians.
Description
Progesterone capsules contain micronized bioidentical progesterone, a hormone that is molecularly identical to the progesterone naturally produced by the human body. Micronization significantly improves absorption and bioavailability when taken orally. Progesterone plays essential roles beyond reproductive function, including regulation of the menstrual cycle, support of sleep quality, modulation of mood and anxiety, maintenance of bone density, and counterbalancing the effects of estrogen throughout the body.
Capsules are available in two formulations: Immediate-release (IR) — delivers progesterone rapidly, creating higher peak levels beneficial for sleep support. The sedative properties make IR particularly useful at bedtime for women experiencing sleep disturbances. Sustained-release (SR) — releases progesterone gradually over an extended period, providing stable hormone levels with reduced sedative effects. This formulation is preferable for women who need consistent progesterone levels without pronounced drowsiness.
During perimenopause and menopause, progesterone levels typically decline earlier and more dramatically than estrogen, often contributing to irregular cycles, sleep disturbances, mood changes, anxiety, and symptoms of estrogen dominance. For postmenopausal women receiving estrogen therapy, adequate progesterone is essential for protecting the endometrial lining and reducing the risk of uterine hyperplasia or cancer.
What To Expect
Progesterone capsules are taken orally with water, typically once daily. IR formulations are usually taken in the evening or at bedtime due to their sedative properties, while SR formulations may be taken at any consistent time of day as directed by your provider. Many women taking IR progesterone at bedtime notice improvements in sleep quality within the first week of treatment. Other symptoms such as mood stability, anxiety reduction, and menstrual regulation typically improve over 4–8 weeks as hormone levels stabilize.
Individual response varies based on baseline hormone levels, symptom severity, formulation type, and dosing. Women taking IR formulations may initially experience drowsiness or dizziness, which typically indicates effective absorption and often lessens with continued use. SR formulations generally produce less pronounced sedation while maintaining therapeutic hormone levels.
How To Use
Take one capsule by mouth at the prescribed time each day, with or without food. Swallow capsules whole with water—do not crush, chew, or open capsules. IR formulations are typically taken in the evening or at bedtime. SR formulations may be taken at any consistent time as directed by your provider. Consistent daily administration is important for maintaining stable hormone levels and optimal therapeutic effect.
Safety Information
Progesterone capsules are generally well-tolerated. Potential side effects may include drowsiness, dizziness, headache, breast tenderness, bloating, or mood changes. IR formulations may cause more pronounced sedation. Progesterone is contraindicated in individuals with active blood clots, liver disease, undiagnosed vaginal bleeding, or known hormone-sensitive malignancies. Women with an intact uterus using estrogen therapy require progesterone for endometrial protection. Avoid driving or operating machinery if you experience drowsiness, particularly with IR formulations.